{"id":108435,"date":"2026-06-29T09:56:12","date_gmt":"2026-06-29T09:56:12","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/123-trichlorpropan\/"},"modified":"2026-06-29T09:56:12","modified_gmt":"2026-06-29T09:56:12","slug":"123-trichlorpropan","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/cs\/fact\/123-trichlorpropan\/","title":{"rendered":"1,2,3-trichlorpropan"},"content":{"rendered":"

Odhady sou\u010dasn\u00e9ho po\u010dtu pracovn\u00edk\u016f v EU vystaven\u00fdch 1,2,3-trichlorpropanu (1,2,3-TCP) nejsou k dispozici. Za hlavn\u00ed cestu expozice je pova\u017eov\u00e1na inhalace, a\u010dkoli pracovn\u00edci mohou b\u00fdt vystaveni tak\u00e9 derm\u00e1ln\u00edm kontaktem.<\/p><\/blockquote>\n

1,2,3-TCP je klasifikov\u00e1n jako karcinogen kategorie 1B (podle CLP na\u0159\u00edzen\u00ed o klasifikaci ozna\u010dov\u00e1n\u00ed a balen\u00ed l\u00e1tek a sm\u011bs\u00ed), co\u017e znamen\u00e1, \u017ee se na z\u00e1klad\u011b d\u016fkaz\u016f u zv\u00ed\u0159at p\u0159edpokl\u00e1d\u00e1 jeho karcinogenn\u00ed potenci\u00e1l pro \u010dlov\u011bka.<\/p>\n

Nejsou k dispozici \u017e\u00e1dn\u00e9 \u00fadaje o tom, zda 1,2,3-TCP zp\u016fsobuje rakovinu u lid\u00ed. Studie na zv\u00ed\u0159atech ukazuj\u00ed, \u017ee dlouhodob\u00e1 expozice t\u00e9to l\u00e1tce m\u016f\u017ee zp\u016fsobit n\u00e1dory na v\u00edce m\u00edstech, nap\u0159\u00edklad v dutin\u011b \u00fastn\u00ed a v p\u0159ed\u017ealudku.<\/p>\n

Kde se vyskytuj\u00ed rizika<\/h2>\n

Hlavn\u00ed vyu\u017eit\u00ed 1,2,3-TCP je jako monomer p\u0159i v\u00fdrob\u011b polymer\u016f nebo jako meziprodukt p\u0159i v\u00fdrob\u011b jin\u00fdch l\u00e1tek (pesticid\u016f, 2,3-dichlorpropenu, polysulfid\u016f a hexafluorpropylenu). 1,2,3-TCP m\u016f\u017ee z\u016fstat jako ne\u010distota v n\u011bkter\u00fdch z t\u011bchto chemick\u00fdch l\u00e1tek. 1,2,3-TCP vznik\u00e1 ve v\u00fdznamn\u00e9m mno\u017estv\u00ed jako vedlej\u0161\u00ed produkt p\u0159i v\u00fdrob\u011b epichlorhydrinu, kdy se k allylchloridu p\u0159id\u00e1v\u00e1 chlor. Tento proces prob\u00edh\u00e1 v uzav\u0159en\u00fdch syst\u00e9mech.
\nObecn\u011b se zd\u00e1, \u017ee expozice na pracovi\u0161ti je omezen\u00e1 d\u00edky manipulaci za p\u0159\u00edsn\u011b kontrolovan\u00fdch podm\u00ednek. Hlavn\u00ed \u010dinnost\u00ed, p\u0159i kter\u00e9 je expozice mo\u017en\u00e1, je manu\u00e1ln\u00ed \u00fadr\u017eba nebo \u010di\u0161t\u011bn\u00ed.<\/p>\n

V\u00edce o l\u00e1tce<\/h2>\n

V \u010dist\u00e9 form\u011b je 1,2,3-TCP bezbarv\u00e1 a\u017e \u017elut\u00e1 kapalina s omezenou rozpustnost\u00ed ve vod\u011b, siln\u00fdm z\u00e1pachem podobn\u00fdm chloroformu, m\u00edrnou t\u011bkavost\u00ed a vysokou ho\u0159lavost\u00ed. Jedn\u00e1 se o \u010dlov\u011bkem vyrobenou chemik\u00e1lii, kter\u00e1 se v \u017eivotn\u00edm prost\u0159ed\u00ed vyskytuje v d\u016fsledku antropogenn\u00ed \u010dinnosti.
\nV sou\u010dasn\u00e9 dob\u011b se p\u0159ipravuje z\u00e1vazn\u00e1 limitn\u00ed hodnota expozice na pracovi\u0161ti platn\u00e1 pro celou EU.<\/p>\n

Rizika, kter\u00e1 mohou nastat<\/h2>\n

\u00dadaje o akutn\u00ed toxicit\u011b u lid\u00ed jsou omezeny na mal\u00fd po\u010det p\u0159\u00edpadov\u00fdch studi\u00ed, kter\u00e9 popisuj\u00ed p\u0159edev\u0161\u00edm jatern\u00ed a neurologick\u00e9 \u00fa\u010dinky po vysok\u00e9, ale obecn\u011b \u0161patn\u011b kvantifikovan\u00e9 peror\u00e1ln\u00ed nebo inhala\u010dn\u00ed expozici. Nejv\u00fdznamn\u011bj\u0161\u00edm zdravotn\u00edm \u00fa\u010dinkem chronick\u00e9 expozice 1,2,3-TCP je karcinogenita. U lid\u00ed nejsou k dispozici \u017e\u00e1dn\u00e9 \u00fadaje. U pokusn\u00fdch zv\u00ed\u0159at vyvol\u00e1v\u00e1 1,2,3-TCP n\u00e1dory na v\u00edce m\u00edstech a s vysokou incidenc\u00ed u my\u0161\u00ed i potkan\u016f. Vzhledem k tomu, \u017ee metabolismus 1,2,3-TCP je kvalitativn\u011b podobn\u00fd v lidsk\u00fdch a hlodav\u010d\u00edch mikrosomech, pova\u017euje se za pravd\u011bpodobn\u00e9, \u017ee je pro \u010dlov\u011bka karcinogenn\u00ed.<\/p>\n

Co m\u016f\u017eete ud\u011blat<\/h2>\n

Na pracovi\u0161ti je nej\u00fa\u010dinn\u011bj\u0161\u00edm zp\u016fsobem prevence expozice n\u00e1hrada 1,2,3-TCP. Tam, kde n\u00e1hrada nen\u00ed mo\u017en\u00e1 a pou\u017eit\u00ed 1,2,3-TCP se nelze vyhnout, mus\u00ed b\u00fdt p\u0159ijata opat\u0159en\u00ed ke sn\u00ed\u017een\u00ed expozice.<\/p>\n

Nej\u00fa\u010dinn\u011bj\u0161\u00edm zp\u016fsobem, jak zabr\u00e1nit expozici 1,2,3-TCP, je v\u00fdvoj a pou\u017e\u00edv\u00e1n\u00ed uzav\u0159en\u00fdch syst\u00e9m\u016f. Pokud to nen\u00ed mo\u017en\u00e9, m\u011bla by b\u00fdt zavedena technick\u00e1 opat\u0159en\u00ed, jako je \u00fa\u010dinn\u00e9 m\u00edstn\u00ed ods\u00e1v\u00e1n\u00ed, dopln\u011bn\u00e9 dobr\u00fdm celkov\u00fdm v\u011btr\u00e1n\u00edm pracovi\u0161t\u011b a pravideln\u00fdmi kontrolami jejich \u00fa\u010dinnosti, aby se zajistilo, \u017ee expozice bude minimalizov\u00e1na na technicky nejni\u017e\u0161\u00ed mo\u017enou m\u00edru.<\/p>\n

Prov\u00e1d\u011bjte pravideln\u00e9 hodnocen\u00ed expozice, abyste ov\u011b\u0159ili, zda jsou zaveden\u00e1 ochrann\u00e1 opat\u0159en\u00ed \u00fa\u010dinn\u00e1, nebo zda je t\u0159eba p\u0159ijmout dal\u0161\u00ed kroky. Pracovn\u00edci mus\u00ed b\u00fdt informov\u00e1ni o \u00fa\u010dinc\u00edch expozice a m\u011bli by b\u00fdt pravideln\u011b pro\u0161kolov\u00e1ni o kontroln\u00edch opat\u0159en\u00edch nezbytn\u00fdch pro bezpe\u010dnou pr\u00e1ci s 1,2,3-TCP, aby se zabr\u00e1nilo expozici. Doporu\u010duje se zapojen\u00ed l\u00e9ka\u0159e pracovn\u00edho l\u00e9ka\u0159stv\u00ed.<\/p>\n

Zajist\u011bte, aby pracovn\u00edci m\u011bli v p\u0159\u00edpad\u011b pot\u0159eby odpov\u00eddaj\u00edc\u00ed Osobn\u00ed ochranu, jako je ochrann\u00fd od\u011bv a rukavice. Osobn\u00ed ochrana by nem\u011bla b\u00fdt pou\u017e\u00edv\u00e1na jako jedin\u00e9 preventivn\u00ed opat\u0159en\u00ed. P\u0159edem mus\u00ed b\u00fdt zavedeno co nejv\u00edce v\u00fd\u0161e uveden\u00fdch technick\u00fdch a organiza\u010dn\u00edch opat\u0159en\u00ed. Ujist\u011bte se, \u017ee je pou\u017e\u00edv\u00e1na spr\u00e1vn\u00e1 Osobn\u00ed ochrana, jako je ochrana o\u010d\u00ed a obli\u010deje, rukavice, ochrann\u00fd od\u011bv a ochrana d\u00fdchac\u00edch cest. P\u0159i v\u00fdb\u011bru vybaven\u00ed je nav\u00edc nutn\u00e9 vz\u00edt v \u00favahu anatomii pracovn\u00edk\u016f, kte\u0159\u00ed jej budou pou\u017e\u00edvat, a v p\u0159\u00edpad\u011b prost\u0159edk\u016f na ochranu d\u00fdchac\u00edch cest zalo\u017een\u00fdch na p\u0159izp\u016fsoben\u00ed obli\u010deji se d\u016frazn\u011b doporu\u010duje prov\u00e9st u ka\u017ed\u00e9 osoby test t\u011bsnosti (fit test). V\u0161ichni pracovn\u00edci by nav\u00edc m\u011bli b\u00fdt pou\u010deni, aby si p\u0159ed p\u0159est\u00e1vkou nebo vstupem do jin\u00fdch prostor \u0159\u00e1dn\u011b umyli ruce a na konci ka\u017ed\u00e9 sm\u011bny se umyli a p\u0159evl\u00e9kli.<\/p>\n

Osobn\u00ed ochrana by m\u011bla b\u00fdt pou\u017e\u00edv\u00e1na pouze jako posledn\u00ed mo\u017enost a zva\u017eov\u00e1na pouze do\u010dasn\u011b, po vy\u010derp\u00e1n\u00ed mo\u017en\u00fdch technick\u00fdch \u0159e\u0161en\u00ed.<\/p>\n

Reference: ECHA<\/em><\/p>\n","protected":false},"template":"","carcinogens":[8682],"class_list":["post-108435","fact","type-fact","status-publish","hentry","carcinogens-123-trichlorpropan"],"yoast_head":"\n1,2,3-trichlorpropan - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"Be aware of what you work with! We collected all the important information these causing substances in easy-to-understand factsheets.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stopcarcinogensatwork.eu\/cs\/fact\/123-trichlorpropan\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"1,2,3-trichlorpropan\" \/>\n<meta property=\"og:description\" content=\"Be aware of what you work with! 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