{"id":98102,"date":"2024-01-04T09:27:50","date_gmt":"2024-01-04T09:27:50","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/o-toluidin\/"},"modified":"2026-07-22T14:14:38","modified_gmt":"2026-07-22T14:14:38","slug":"o-toluidin","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/cs\/fact\/o-toluidin\/","title":{"rendered":"o-Toluidin"},"content":{"rendered":"

Odhady aktu\u00e1ln\u00edho po\u010dtu pracovn\u00edk\u016f vystaven\u00fdch p\u016fsoben\u00ed orto-toluidinu (o-Toluidinu) v EU nejsou k dispozici. V roce 2011 se na z\u00e1klad\u011b \u00fadaj\u016f z let 2006\/2007 odhadovalo, \u017ee t\u00e9to l\u00e1tce je vystaveno 5 500 pracovn\u00edk\u016f, z nich\u017e 3 100 pracovalo ve v\u00fdrob\u011b chemik\u00e1li\u00ed a chemick\u00fdch v\u00fdrobk\u016f, ve v\u00fdrob\u011b um\u011bl\u00fdch vl\u00e1ken nebo ve v\u00fdrob\u011b pry\u017eov\u00fdch v\u00fdrobk\u016f. <\/p><\/blockquote>\n

K expozici doch\u00e1z\u00ed p\u0159edev\u0161\u00edm vdechov\u00e1n\u00edm a absorpc\u00ed p\u0159es k\u016f\u017ei; nen\u00ed nutn\u00fd p\u0159\u00edm\u00fd kontakt s k\u016f\u017e\u00ed. M\u016f\u017ee doj\u00edt tak\u00e9 k absorpci p\u0159i po\u017eit\u00ed a p\u0159i kontaktu s o\u010dima. <\/p>\n

o-Toluidin je podle CLP na\u0159\u00edzen\u00ed o klasifikaci ozna\u010dov\u00e1n\u00ed a balen\u00ed l\u00e1tek a sm\u011bs\u00ed za\u0159azen jako harmonizovan\u00e1 polo\u017eka do kategorie karcinogenity 1B (p\u0159edpokl\u00e1dan\u00fd karcinogenn\u00ed potenci\u00e1l pro \u010dlov\u011bka zalo\u017een\u00fd p\u0159ev\u00e1\u017en\u011b na d\u016fkazech z\u00edskan\u00fdch na pokusn\u00fdch zv\u00ed\u0159atech). U lid\u00ed m\u016f\u017ee o-Toluidin zp\u016fsobit rakovinu mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e. K celkov\u00e9 z\u00e1t\u011b\u017ei organismu m\u016f\u017ee p\u0159isp\u00edvat i pronik\u00e1n\u00ed l\u00e1tkou p\u0159es k\u016f\u017ei. <\/p>\n

Kde se vyskytuj\u00ed rizika<\/h2>\n

Expozice o-Toluidinu byla v minulosti mnohem vy\u0161\u0161\u00ed, ale i dnes k n\u00ed m\u016f\u017ee doch\u00e1zet v n\u011bkolika pracovn\u00edch prost\u0159ed\u00edch, zejm\u00e9na v chemick\u00e9m pr\u016fmyslu p\u0159i v\u00fdrob\u011b, zpracov\u00e1n\u00ed, odb\u011bru vzork\u016f nebo p\u0159eprav\u011b o-Toluidinu, p\u0159\u00edpadn\u011b p\u0159i jeho pou\u017eit\u00ed jako meziproduktu, zejm\u00e9na p\u0159i v\u00fdrob\u011b barviv a p\u0159i v\u00fdrob\u011b p\u0159\u00edpravk\u016f na ochranu rostlin. K expozici m\u016f\u017ee doch\u00e1zet i v d\u016fsledku uvol\u0148ov\u00e1n\u00ed z azobarviv nebo barviv pou\u017e\u00edvan\u00fdch v textiln\u00edm pr\u016fmyslu, tiskov\u00fdch barv\u00e1ch, plastech, mazivech a v\u00fdrobc\u00edch z miner\u00e1ln\u00edch olej\u016f; uvol\u0148ov\u00e1n\u00ed z p\u0159\u00edsad b\u011bhem tepeln\u00fdch proces\u016f, jako je vulkanizace; tepeln\u00e9ho rozkladu organick\u00fdch pojiv, zejm\u00e9na p\u0159i odl\u00e9vac\u00edch procesech; manipulace s materi\u00e1ly obsahuj\u00edc\u00edmi uheln\u00fd dehet nebo jejich zah\u0159\u00edv\u00e1n\u00ed; laboratorn\u00edch a v\u00fdzkumn\u00fdch \u010dinnost\u00ed. <\/p>\n

V\u00edce o l\u00e1tce<\/h2>\n

o-Toluidin se pr\u016fmyslov\u011b vyr\u00e1b\u00ed nitrac\u00ed Tolenu, p\u0159i\u010dem\u017e vznik\u00e1 sm\u011bs nitrotoluen\u016f; jedn\u00e1 se o nejd\u016fle\u017eit\u011bj\u0161\u00ed ze t\u0159\u00ed izomern\u00edch toluidin\u016f. Je to bezbarv\u00e1 kapalina, a\u010dkoli komer\u010dn\u00ed vzorky jsou \u010dasto na\u017eloutl\u00e9. o-Toluidin je meziproduktem biologick\u00e9ho rozkladu o-nitrotoluenu, a proto je detekov\u00e1n v lokalit\u00e1ch b\u00fdval\u00fdch muni\u010dn\u00edch sklad\u016f. o-Toluidin vznik\u00e1 p\u0159i pyrol\u00fdze.
\nNen\u00ed zn\u00e1mo \u017e\u00e1dn\u00e9 p\u0159\u00edm\u00e9 pou\u017eit\u00ed o-toluidinu pro spot\u0159ebitele, proto\u017ee je jeho pou\u017eit\u00ed v kosmetick\u00fdch p\u0159\u00edpravc\u00edch zak\u00e1z\u00e1no na\u0159\u00edzen\u00edm EU o kosmetick\u00fdch p\u0159\u00edpravc\u00edch. Pou\u017e\u00edv\u00e1n\u00ed azobarviv, kter\u00e1 p\u0159i rozkladu uvol\u0148uj\u00ed o-Toluidin, nen\u00ed v EU povoleno pro textilie a jin\u00e9 spot\u0159ebn\u00ed v\u00fdrobky. Expozice spot\u0159ebitel\u016f a \u017eivotn\u00edho prost\u0159ed\u00ed v d\u016fsledku uvol\u0148ov\u00e1n\u00ed z spot\u0159ebn\u00edch v\u00fdrobk\u016f se proto jev\u00ed jako zanedbateln\u00e1. <\/p>\n

Pro o-Toluidin plat\u00ed v r\u00e1mci cel\u00e9 EU z\u00e1vazn\u00e1 mezn\u00ed hodnota expozice na pracovi\u0161ti ve v\u00fd\u0161i 0,5 mg\/m\u00b3 ve vzduchu.<\/p>\n

Zdravotn\u00ed rizika, kter\u00e1 mohou nastat<\/h2>\n

o-Toluidin se po vdechnut\u00ed a p\u0159es k\u016f\u017ei dob\u0159e vst\u0159eb\u00e1v\u00e1. Or\u00e1ln\u00ed expozice na pracovi\u0161ti nen\u00ed relevantn\u00ed.
\nNeexistuj\u00ed \u017e\u00e1dn\u00e9 zpr\u00e1vy o \u00fa\u010dinc\u00edch po akutn\u00ed expozici, av\u0161ak na z\u00e1klad\u011b \u00fadaj\u016f z experiment\u016f na zv\u00ed\u0159atech se p\u0159edpokl\u00e1d\u00e1 akutn\u00ed dr\u00e1\u017ediv\u00fd \u00fa\u010dinek na o\u010di a k\u016f\u017ei. <\/p>\n

Za relevantn\u00ed zdravotn\u00ed \u00fa\u010dinek u lid\u00ed se pova\u017euje rakovina mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e. V n\u011bkter\u00fdch \u010dlensk\u00fdch st\u00e1tech se jedn\u00e1 o uznan\u00e9 nemoci z povol\u00e1n\u00ed spojen\u00e9 s d\u0159\u00edv\u011bj\u0161\u00ed expozic\u00ed o-Toluidinu. <\/p>\n

Latentn\u00ed doba mezi expozic\u00ed a v\u00fdskytem rakoviny mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e souvisej\u00edc\u00ed s o-Toluidinem se zna\u010dn\u011b li\u0161\u00ed, obvykle se v\u0161ak odhaduje na 15 a\u017e 40 let.<\/strong><\/p>\n

Co m\u016f\u017eete ud\u011blat<\/h2>\n

V p\u0159\u00edpadech, kde je to mo\u017en\u00e9, je t\u0159eba zv\u00e1\u017eit nahrazen\u00ed l\u00e1tky jinou. Aby se p\u0159ede\u0161lo nep\u0159\u00edzniv\u00fdm \u00fa\u010dink\u016fm na zdrav\u00ed, je nanejv\u00fd\u0161 d\u016fle\u017eit\u00e9 sn\u00ed\u017eit expozici pod z\u00e1vaznou mezn\u00ed hodnotu pro expozici na pracovi\u0161ti nebo zdravotn\u00ed mezn\u00ed hodnotu. V pr\u016fmyslov\u00fdch procesech pat\u0159\u00ed mezi p\u0159\u00edklady technick\u00fdch kontroln\u00edch opat\u0159en\u00ed uzav\u0159en\u00e9 syst\u00e9my, celoplo\u0161n\u00e9 odv\u011btr\u00e1v\u00e1n\u00ed a lok\u00e1ln\u00ed ods\u00e1v\u00e1n\u00ed. K expozici m\u016f\u017ee doj\u00edt i p\u0159i pr\u00e1ci s uzav\u0159en\u00fdmi syst\u00e9my, nap\u0159. p\u0159i odb\u011bru vzork\u016f nebo \u00fadr\u017eb\u011b. V t\u011bchto p\u0159\u00edpadech jsou d\u016fle\u017eit\u00e1 m\u011b\u0159en\u00ed a kontroln\u00ed opat\u0159en\u00ed. Mezi dal\u0161\u00ed doporu\u010den\u00e9 pracovn\u00ed postupy pat\u0159\u00ed poskytov\u00e1n\u00ed informac\u00ed o rizic\u00edch a \u0161kolen\u00ed zam\u011bstnanc\u016f a dodr\u017eov\u00e1n\u00ed obecn\u00fdch standard\u016f pracovn\u00ed hygieny v prostorech, kde se manipuluje s chemick\u00fdmi l\u00e1tkami. Pracovn\u00edci prov\u00e1d\u011bj\u00edc\u00ed \u00fadr\u017ebu a \u00faklid by m\u011bli b\u00fdt rovn\u011b\u017e pro\u0161koleni. Doporu\u010duje se zapojit pracovn\u00edho l\u00e9ka\u0159e. Je t\u0159eba si uv\u011bdomit, \u017ee posouzen\u00ed expozice by m\u011blo b\u00fdt podpo\u0159eno biomonitoringem, je-li to podle vnitrost\u00e1tn\u00edch pr\u00e1vn\u00edch p\u0159edpis\u016f mo\u017en\u00e9, proto\u017ee o-Toluidin se dob\u0159e vst\u0159eb\u00e1v\u00e1 k\u016f\u017e\u00ed. Pracovn\u00edci mus\u00ed b\u00fdt sezn\u00e1meni s \u00fa\u010dinky expozice. Osobn\u00ed ochrana by m\u011bla b\u00fdt pou\u017e\u00edv\u00e1na pouze jako posledn\u00ed mo\u017enost, a\u017e po zaveden\u00ed mo\u017en\u00fdch technick\u00fdch \u0159e\u0161en\u00ed. <\/p>\n

Zdroje: ECHA, IOM, SCOEL<\/p>\n","protected":false},"template":"","carcinogens":[8120],"class_list":["post-98102","fact","type-fact","status-publish","hentry","carcinogens-o-toluidin"],"yoast_head":"\no-Toluidin - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"Be aware of what you work with! We collected all the important information these causing substances in easy-to-understand factsheets.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stopcarcinogensatwork.eu\/cs\/fact\/o-toluidin\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"o-Toluidin\" \/>\n<meta property=\"og:description\" content=\"Be aware of what you work with! 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