{"id":106384,"date":"2026-06-29T10:02:28","date_gmt":"2026-06-29T10:02:28","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/12-dichlorpropan\/"},"modified":"2026-06-29T10:02:28","modified_gmt":"2026-06-29T10:02:28","slug":"12-dichlorpropan","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/da\/fact\/12-dichlorpropan\/","title":{"rendered":"1,2-dichlorpropan"},"content":{"rendered":"

Der foreligger ingen sk\u00f8n over det aktuelle antal arbejder, der er udsat for 1,2-dichlorpropan (1,2-DPC) i EU. Ind\u00e5nding anses for at v\u00e6re den prim\u00e6re eksponeringsvej, selv om arbejder ogs\u00e5 kan blive udsat for stoffet gennem hudkontakt. <\/p><\/blockquote>\n

1,2-DPC er klassificeret som carcinogen i kategori 1B (i henhold til CLP-forordningen), hvilket betyder, at det p\u00e5 baggrund af dyrefors\u00f8g formodes at have carcinogene effekter hos mennesker.<\/p>\n

De toksiske virkninger har omfattet lever- og nyreskader, intravaskul\u00e6r koagulation, h\u00e6molytisk an\u00e6mi og forskellige symptomer p\u00e5 centralnervesystemet.<\/p>\n

Hvor risici opst\u00e5r<\/h2>\n

1,2-DCP er et biprodukt, der dannes i betydelige m\u00e6ngder under fremstillingen af propylenoxid ved hj\u00e6lp af chlorhydrin-processen til produktion af Epiklorhydrin. 1,2-DCP blev tidligere anvendt som jorddesinfektionsmiddel, kemisk mellemprodukt samt som industrielt opl\u00f8sningsmiddel. Det fandtes i malingfjernere, lakker og midler til fjernelse af m\u00f8beloverfladebehandling. Det anvendes ikke l\u00e6ngere som jorddesinfektionsmiddel. <\/p>\n

I \u00f8jeblikket anvendes stoffet hovedsageligt som mellemprodukt i fremstillingen af perchlorethylen og andre klorerede kemikalier.
\nGenerelt synes eksponeringen p\u00e5 arbejdspladsen at v\u00e6re begr\u00e6nset, da h\u00e5ndteringen foreg\u00e5r under strengt kontrollerede forhold. Den prim\u00e6re aktivitet, hvor eksponering kan forekomme, er i forbindelse med manuelle vedligeholdelses- eller reng\u00f8ringsopgaver. <\/p>\n

Mere om stoffet<\/h2>\n

I sin rene form er 1,2-DPC en farvel\u00f8s, brandfarlig, flydende v\u00e6ske med en lugt, der minder om kloroform. Stoffet kan blandes med de fleste organiske opl\u00f8sningsmidler, s\u00e5som alkoholer, estere og ketoner, samt med aromatiske, alifatiske og klorerede kulbrinter.
\nDer udarbejdes i \u00f8jeblikket en EU-d\u00e6kkende, bindende gr\u00e6nsev\u00e6rdi for erhvervsm\u00e6ssig eksponering. <\/p>\n

Farer, der kan opst\u00e5<\/h2>\n

Kortvarig eksponering for 1,2-DCP hos mennesker kan for\u00e5rsage irritation samt lever- og nyrefunktionsforstyrrelser efter oral og dermal absorption. Ved meget h\u00f8je koncentrationer er der rapporteret om depression af centralnervesystemet.
\nVed langvarig eksponering er den mest kritiske virkning hos mennesker carcinogenitet, n\u00e6rmere bestemt forekomsten af tumorer i galdevejene (cholangiocarcinom). <\/p>\n

Hvad du kan g\u00f8re<\/h2>\n

P\u00e5 arbejdspladsen er den mest effektive m\u00e5de at forebygge eksponering p\u00e5 ved at erstatte 1,2-DCP. Hvor substitution ikke er mulig, og brugen af 1,2-DCP ikke kan undg\u00e5s, skal der tr\u00e6ffes foranstaltninger til at reducere eksponeringen.
\nDen mest effektive m\u00e5de at undg\u00e5 eksponering for 1,2-DCP p\u00e5 er at udvikle og anvende lukkede systemer. Hvor dette ikke er muligt, b\u00f8r der iv\u00e6rks\u00e6ttes tekniske foranstaltninger, s\u00e5som effektiv lokal udsugning, suppleret med god generel ventilation p\u00e5 arbejdspladsen og regelm\u00e6ssige kontroller af deres effektivitet, for at sikre, at eksponeringen minimeres s\u00e5 meget som teknisk muligt <\/p>\n

Al produktion af 1,2-DPC foreg\u00e5r i lukkede systemer. Der opst\u00e5r eksponering, n\u00e5r disse lukkede systemer \u00e5bnes i forbindelse med rutinem\u00e6ssig vedligeholdelse, inspektioner eller reng\u00f8ring. I s\u00e5danne tilf\u00e6lde skal der anvendes tekniske foranstaltninger og personlige v\u00e6rnemidler, herunder \u00e5ndedr\u00e6tsv\u00e6rn. <\/p>\n

Gennemf\u00f8r foranstaltninger, der sikrer en god generel hygiejne p\u00e5 arbejdspladsen med regelm\u00e6ssig reng\u00f8ring og hygiejnisk opbevaring. Efter den indledende eksponeringsm\u00e5ling til Risikovurdering skal der foretages periodiske eksponeringsvurderinger for at kontrollere, om de tekniske foranstaltninger, der er iv\u00e6rksat, er effektive, eller om der skal tr\u00e6ffes yderligere foranstaltninger. En streng begr\u00e6nsning af den tid, arbejdere tilbringer i det eksponerede arbejdsmilj\u00f8 (f.eks. via skiftehold), samt begr\u00e6nsning af adgangen til disse arbejdspladser er vigtige foranstaltninger til at reducere eksponeringen. Arbejdere skal v\u00e6re opm\u00e6rksomme p\u00e5 de mulige risici forbundet med opgaver, der involverer 1,2-DPC, og arbejdsgiverne skal regelm\u00e6ssigt uddanne og instruere dem i, hvordan man arbejder sikkert med 1,2-DPC. <\/p>\n

Der skal foretages medicinsk helbredsoverv\u00e5gning af arbejdere, der uds\u00e6ttes for farlige stoffer, og de b\u00f8r derfor opfordres til at indberette tidlige symptomer s\u00e5som \u00e5ndedr\u00e6tsbesv\u00e6r eller hudallergier.
\nDesuden b\u00f8r arbejdere undervises i vigtigheden af god personlig hygiejne. Der skal stilles passende vaske- og toiletfaciliteter til r\u00e5dighed, og arbejdere skal have rigelig tid til at udf\u00f8re hygiejneforanstaltninger. <\/p>\n

S\u00f8rg for, at arbejderne har tilstr\u00e6kkeligt personligt beskyttelsesudstyr, s\u00e5som beskyttelsest\u00f8j og handsker, hvis det er n\u00f8dvendigt. Personligt beskyttelsesudstyr b\u00f8r kun anvendes som en sidste udvej og kun betragtes som en midlertidig l\u00f8sning, efter at alle mulige tekniske og organisatoriske l\u00f8sninger er blevet udt\u00f8mt. <\/p>\n

Kilder: ECHA, ATSDR 2021<\/em><\/p>\n","protected":false},"template":"","carcinogens":[8546],"class_list":["post-106384","fact","type-fact","status-publish","hentry","carcinogens-12-dichlorpropan"],"yoast_head":"\n1,2-dichlorpropan - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"Be aware of what you work with! We collected all the important information these causing substances in easy-to-understand factsheets.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stopcarcinogensatwork.eu\/da\/fact\/12-dichlorpropan\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"1,2-dichlorpropan\" \/>\n<meta property=\"og:description\" content=\"Be aware of what you work with! 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