{"id":106508,"date":"2026-06-29T09:56:12","date_gmt":"2026-06-29T09:56:12","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/123-trichlorpropan\/"},"modified":"2026-06-29T09:56:12","modified_gmt":"2026-06-29T09:56:12","slug":"123-trichlorpropan","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/da\/fact\/123-trichlorpropan\/","title":{"rendered":"1,2,3-trichlorpropan"},"content":{"rendered":"

Der foreligger ingen sk\u00f8n over det aktuelle antal arbejder i EU, der er udsat for 1,2,3-trichlorpropan (1,2,3-TPC). Ind\u00e5nding anses for at v\u00e6re den prim\u00e6re eksponeringsvej, selvom arbejder ogs\u00e5 kan blive udsat via hudkontakt. <\/p><\/blockquote>\n

1,2,3-TPC er klassificeret som carcinogen i kategori 1B (i henhold til CLP-forordningen), hvilket betyder, at det p\u00e5 baggrund af dyrefors\u00f8g formodes at have carcinogene effekter hos mennesker.<\/p>\n

Der foreligger ingen data om, hvorvidt 1,2,3-TCP for\u00e5rsager kr\u00e6ft hos mennesker. Dyrefors\u00f8g viser, at langvarig eksponering for dette stof kan for\u00e5rsage tumorer flere steder, f.eks. i mundhulen og i formaven. <\/p>\n

Hvor risici opst\u00e5r<\/h2>\n

1,2,3-TPC anvendes prim\u00e6rt som monomer ved fremstilling af polymerer eller som mellemprodukt i produktionen af andre stoffer (Pesticider, 2,3-dichlorpropen, polysulfider og hexafluorpropylen). 1,2,3-TCP kan forekomme som en urenhed i nogle af disse kemikalier. 1,2,3-TCP produceres i betydelige m\u00e6ngder som et biprodukt under fremstillingen af Epiklorhydrin, n\u00e5r der tils\u00e6ttes klor til allylchlorid. Denne proces finder sted i lukkede systemer.
\nGenerelt synes eksponeringen p\u00e5 arbejdspladsen at v\u00e6re begr\u00e6nset, da h\u00e5ndteringen foreg\u00e5r under strengt kontrollerede forhold. Den prim\u00e6re aktivitet, hvor eksponering er mulig, er i forbindelse med manuelle vedligeholdelses- eller reng\u00f8ringsopgaver. <\/p>\n

Mere om stoffet<\/h2>\n

I sin rene form er 1,2,3-TPC en farvel\u00f8s til gul v\u00e6ske med begr\u00e6nset opl\u00f8selighed i vand, en st\u00e6rk kloroformlignende lugt, moderat flygtighed og h\u00f8j brandbarhed. Det er et syntetisk kemikalie, der forekommer i milj\u00f8et som f\u00f8lge af menneskelig aktivitet.
\nDer udarbejdes i \u00f8jeblikket en EU-d\u00e6kkende, bindende gr\u00e6nsev\u00e6rdi for erhvervsm\u00e6ssig eksponering. <\/p>\n

Farer, der kan opst\u00e5<\/h2>\n

Data om akut toksicitet hos mennesker er begr\u00e6nset til et lille antal caserapporter, der prim\u00e6rt beskriver lever- og neurologiske virkninger efter h\u00f8j, men generelt ikke velkvantificeret, oral eller inhalativ eksponering. Den mest relevante sundhedsm\u00e6ssige virkning af kronisk eksponering for 1,2,3-TCP er carcinogen virkning. Der foreligger ingen data fra mennesker. Hos fors\u00f8gsdyr inducerer 1,2,3-TCP tumorer p\u00e5 flere steder og med h\u00f8j forekomst hos b\u00e5de mus og rotter. Da metabolismen af 1,2,3-TCP er kvalitativt ens i mikrosomer fra mennesker og gnavere, anses stoffet for sandsynligvis at v\u00e6re carcinogen for mennesker. <\/p>\n

Hvad du kan g\u00f8re<\/h2>\n

P\u00e5 arbejdspladsen er den mest effektive m\u00e5de at forebygge eksponering p\u00e5 ved at erstatte 1,2,3-TCP. Hvor det ikke er muligt at erstatte stoffet, og brugen af 1,2,3-TCP ikke kan undg\u00e5s, skal der tr\u00e6ffes foranstaltninger til at reducere eksponeringen. <\/p>\n

Den mest effektive m\u00e5de at undg\u00e5 eksponering for 1,2,3-TCP p\u00e5 er at udvikle og anvende lukkede systemer. Hvor dette ikke er muligt, b\u00f8r der iv\u00e6rks\u00e6ttes tekniske foranstaltninger, s\u00e5som effektiv lokal udsugning, suppleret med god generel ventilation p\u00e5 arbejdspladsen og regelm\u00e6ssige kontroller af deres effektivitet, for at sikre, at eksponeringen minimeres s\u00e5 meget som teknisk muligt. <\/p>\n

Gennemf\u00f8r regelm\u00e6ssige eksponeringsvurderinger for at kontrollere, om de iv\u00e6rksatte beskyttelsesforanstaltninger er effektive, eller om der skal tr\u00e6ffes yderligere foranstaltninger. Arbejderne skal v\u00e6re opm\u00e6rksomme p\u00e5 virkningerne af eksponering og b\u00f8r regelm\u00e6ssigt modtage undervisning i de n\u00f8dvendige kontrolforanstaltninger for at arbejde sikkert med 1,2,3-TCP og dermed forhindre eksponering. Det anbefales at inddrage en arbejdsmediciner. <\/p>\n

S\u00f8rg for, at arbejderne har passende udstyr til personlig beskyttelse, s\u00e5som beskyttelsest\u00f8j og handsker, hvis det er n\u00f8dvendigt. Udstyr til personlig beskyttelse b\u00f8r ikke anvendes som den eneste forebyggende foranstaltning. S\u00e5 mange af de ovenn\u00e6vnte tekniske og organisatoriske foranstaltninger som muligt skal v\u00e6re iv\u00e6rksat p\u00e5 forh\u00e5nd. S\u00f8rg for, at der anvendes det rigtige udstyr for personlig beskyttelse, s\u00e5som \u00f8jen- og ansigtsbeskyttelse, handsker, beskyttelsest\u00f8j og \u00e5ndedr\u00e6tsbeskyttelse. Desuden skal der ved valg af udstyr tages hensyn til de arbejderes anatomi, der skal bruge det, og i tilf\u00e6lde af \u00e5ndedr\u00e6tsbeskyttelsesudstyr, der er baseret p\u00e5 tilpasning til ansigtet, anbefales det st\u00e6rkt, at der foretages en tilpasningstest p\u00e5 hver enkelt person. Derudover b\u00f8r alle arbejderne instrueres i at vaske h\u00e6nderne grundigt, f\u00f8r de holder pause eller g\u00e5r ind i et andet omr\u00e5de, samt at vaske sig og skifte t\u00f8j ved afslutningen af hvert skift. <\/p>\n

Personlig beskyttelse b\u00f8r kun anvendes som en sidste udvej og kun betragtes som en midlertidig l\u00f8sning, efter at alle mulige tekniske l\u00f8sninger er blevet udt\u00f8mt.<\/p>\n

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