{"id":106533,"date":"2026-06-29T09:56:12","date_gmt":"2026-06-29T09:56:12","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/123-trikloropropan\/"},"modified":"2026-06-29T09:56:12","modified_gmt":"2026-06-29T09:56:12","slug":"123-trikloropropan","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/hr\/fact\/123-trikloropropan\/","title":{"rendered":"1,2,3-trikloropropan"},"content":{"rendered":"

Procjene trenutnog broja izlo\u017eenih radnika 1,2,3-trikloropropanu (1,2,3-TPC) u EU nisu dostupne. Udisanje se smatra primarnim putem izlo\u017eenosti, iako radnici mogu biti izlo\u017eeni i putem kontakta s ko\u017eom. <\/p><\/blockquote>\n

1,2,3-TPC je klasificiran kao karcinogeni spoj kategorije 1B (prema CLP uredbi), \u0161to zna\u010di da se pretpostavlja da ima karcinogeni potencijal za ljude, na temelju dokaza na \u017eivotinjama.<\/p>\n

Nema dostupnih podataka o tome uzrokuje li 1,2,3-TCP rak kod ljudi. Studije na \u017eivotinjama pokazuju da dugotrajna izlo\u017eenost ovoj tvari mo\u017ee uzrokovati tumore na vi\u0161e mjesta, kao \u0161to su u usnoj \u0161upljini i pred\u017eelucu. <\/p>\n

Gdje se javljaju rizici<\/h2>\n

Primarna upotreba 1,2,3-TPC je kao monomer u proizvodnji polimera ili kao me\u0111uprodukt u proizvodnji drugih tvari (pesticidi, 2,3-dikloropropen, polisulfidi i heksafluoropropilen). 1,2,3-TCP mo\u017ee ostati kao ne\u010disto\u0107a u nekim od ovih kemikalija. 1,2,3-TCP se proizvodi u zna\u010dajnim koli\u010dinama kao nusprodukt tijekom proizvodnje epiklorohidrina kada se klor dodaje alil kloridu. Ovaj se proces odvija u zatvorenim sustavima.
\n Op\u0107enito, izlo\u017eenost na radnom mjestu \u010dini se ograni\u010denom zbog rukovanja u strogo kontroliranim uvjetima. Glavna aktivnost u kojoj je mogu\u0107a izlo\u017eenost je tijekom ru\u010dnog odr\u017eavanja ili \u010di\u0161\u0107enja. <\/p>\n

Vi\u0161e o supstanci<\/h2>\n

U svom \u010distom obliku, 1,2,3-TPC je bezbojna do \u017euta teku\u0107ina s ograni\u010denom topljivo\u0161\u0107u u vodi, jakim mirisom sli\u010dnim kloroformu, umjerenom hlapljivo\u0161\u0107u i visokom zapaljivo\u0161\u0107u. To je umjetna kemikalija, prisutna u okoli\u0161u kao rezultat antropogene aktivnosti.
\n Trenutno je u pripremi obvezuju\u0107a grani\u010dna vrijednost izlo\u017eenosti na radu za cijelu EU. <\/p>\n

Opasnosti koje se mogu pojaviti<\/h2>\n

Podaci o akutnoj toksi\u010dnosti kod ljudi ograni\u010deni su na mali broj izvje\u0161\u0107a o slu\u010dajevima, koja opisuju prvenstveno u\u010dinke na jetru i neurolo\u0161ke u\u010dinke nakon visoke, ali op\u0107enito ne dobro kvantificirane, oralne ili inhalacijske izlo\u017eenosti. Najrelevantniji zdravstveni u\u010dinak kroni\u010dne izlo\u017eenosti 1,2,3-TCP-u je karcinogenost. Nema dostupnih podataka za ljude. U pokusnim \u017eivotinjama, 1,2,3-TCP inducira tumore na vi\u0161e mjesta i s visokom incidencijom i kod mi\u0161eva i kod \u0161takora. Budu\u0107i da je metabolizam 1,2,3-TCP-a kvalitativno sli\u010dan u ljudskim i glodav\u010devim mikrosomima, smatra se vjerojatnim da je karcinogen za ljude. <\/p>\n

\u0160to mo\u017eete u\u010diniti<\/h2>\n

Na radnom mjestu, naju\u010dinkovitiji na\u010din sprje\u010davanja izlo\u017eenosti je zamjena 1,2,3-TCP-om. Tamo gdje zamjena nije mogu\u0107a i upotreba 1,2,3-TCP-a se ne mo\u017ee izbje\u0107i, moraju se poduzeti mjere za smanjenje izlo\u017eenosti. <\/p>\n

Naju\u010dinkovitiji na\u010din izbjegavanja izlo\u017eenosti 1,2,3-TCP-u je razvoj i kori\u0161tenje zatvorenih sustava. Tamo gdje to nije mogu\u0107e, treba provesti tehni\u010dke mjere poput u\u010dinkovite lokalne ispu\u0161ne ventilacije, uz dobru op\u0107u ventilaciju radnog mjesta i redovite provjere njihove u\u010dinkovitosti, kako bi se osiguralo da se izlo\u017eenost svede na najmanju mogu\u0107u mjeru koliko je to tehni\u010dki mogu\u0107e. <\/p>\n

Redovito provodite procjene izlo\u017eenosti kako biste provjerili jesu li va\u0161e za\u0161titne mjere u\u010dinkovite ili je potrebno poduzeti daljnje mjere. Radnici moraju biti svjesni u\u010dinaka izlo\u017eenosti i trebaju se redovito obu\u010davati o kontrolnim mjerama potrebnim za siguran rad s 1,2,3-TCP-om kako bi se sprije\u010dila izlo\u017eenost. Preporu\u010duje se uklju\u010divanje lije\u010dnika medicine rada. <\/p>\n

Osigurajte da radnici imaju odgovaraju\u0107u osobnu za\u0161titnu opremu, poput za\u0161titne odje\u0107e i rukavica, ako je potrebno. Osobna za\u0161titna oprema ne smije se koristiti kao jedina preventivna mjera. \u0160to vi\u0161e gore navedenih tehni\u010dkih i organizacijskih mjera mora biti prethodno provedeno. Pobrinite se da se koristi odgovaraju\u0107a osobna za\u0161titna oprema, poput za\u0161tite za o\u010di i lice, rukavica, za\u0161titne odje\u0107e i za\u0161tite za disanje. Osim toga, pri odabiru opreme mora se uzeti u obzir anatomija radnika koji \u0107e je koristiti, a u slu\u010daju respiratorne za\u0161titne opreme koja se temelji na prilagodbi licu, toplo se preporu\u010duje da se na svakoj osobi provede test pristajanja. Osim toga, sve radnike treba uputiti da temeljno operu ruke prije pauze ili ulaska u drugi prostor te da se operu i presvuku na kraju svake smjene. <\/p>\n

Osobnu za\u0161titnu opremu treba koristiti samo kao krajnje rje\u0161enje i razmatrati samo privremeno, nakon \u0161to su iscrpljena sva mogu\u0107a tehni\u010dka rje\u0161enja.<\/p>\n

Reference: ECHA<\/em><\/p>\n","protected":false},"template":"","carcinogens":[8643],"class_list":["post-106533","fact","type-fact","status-publish","hentry","carcinogens-123-trikloropropan"],"yoast_head":"\n1,2,3-trikloropropan - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"Be aware of what you work with! We collected all the important information these causing substances in easy-to-understand factsheets.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stopcarcinogensatwork.eu\/hr\/fact\/123-trikloropropan\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"1,2,3-trikloropropan\" \/>\n<meta property=\"og:description\" content=\"Be aware of what you work with! 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