{"id":106564,"date":"2026-06-29T10:02:28","date_gmt":"2026-06-29T10:02:28","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/12-dikloropropan\/"},"modified":"2026-06-29T10:02:28","modified_gmt":"2026-06-29T10:02:28","slug":"12-dikloropropan","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/tr\/fact\/12-dikloropropan\/","title":{"rendered":"1,2-Dikloropropan"},"content":{"rendered":"

AB\u2019de 1,2-dikloropropan (1,2-DPC) exposureuna maruz kalan \u00e7al\u0131\u015fanlar\u0131n mevcut say\u0131s\u0131na ili\u015fkin herhangi bir tahmin bulunmamaktad\u0131r. Soluma, exposureun birincil yolu olarak kabul edilmekle birlikte, \u00e7al\u0131\u015fanlar deri temas\u0131 yoluyla da exposurea maruz kalabilirler. <\/p><\/blockquote>\n

1,2-DPC, (S\u0131n\u0131fland\u0131rma, Etiketleme ve Ambalajlama Y\u00f6netmeli\u011fi\u2019ne g\u00f6re) Carcinogen Kategori 1B olarak s\u0131n\u0131fland\u0131r\u0131lm\u0131\u015ft\u0131r; bu, hayvanlar \u00fczerinde yap\u0131lan ara\u015ft\u0131rmalara dayanarak, bu maddenin insanlar i\u00e7in carcinogen potansiyele sahip oldu\u011fu varsay\u0131ld\u0131\u011f\u0131 anlam\u0131na gelir.<\/p>\n

Toksik etkiler aras\u0131nda karaci\u011fer ve b\u00f6brek hasar\u0131, intravask\u00fcler p\u0131ht\u0131la\u015fma, hemolitik anemi ve \u00e7e\u015fitli merkezi sinir sistemi belirtileri yer almaktad\u0131r.<\/p>\n

Risklerin olu\u015ftu\u011fu yerler<\/h2>\n

1,2-DCP, Epiklorohidrin \u00fcretimi i\u00e7in klorohidrin y\u00f6ntemiyle propilen oksit \u00fcretim s\u00fcrecinde \u00f6nemli miktarlarda ortaya \u00e7\u0131kan bir yan \u00fcr\u00fcnd\u00fcr. 1,2-DCP ge\u00e7mi\u015fte toprak dezenfektan\u0131, kimyasal ara \u00fcr\u00fcn ve end\u00fcstriyel \u00e7\u00f6z\u00fcc\u00fc olarak kullan\u0131lm\u0131\u015ft\u0131r. Boya s\u00f6k\u00fcc\u00fclerinde, verniklerde ve mobilya cilas\u0131 s\u00f6k\u00fcc\u00fclerinde bulunmaktayd\u0131. Art\u0131k toprak dezenfektan\u0131 olarak kullan\u0131lmamaktad\u0131r. <\/p>\n

\u015eu anda, bu maddenin ba\u015fl\u0131ca kullan\u0131m alan\u0131, perkloroetilen ve di\u011fer klorlu kimyasallar\u0131n \u00fcretiminde ara madde olarak kullan\u0131lmas\u0131d\u0131r.
\nGenel olarak, i\u015fyerinde exposure, maddenin s\u0131k\u0131 bir \u015fekilde kontrol edilen ko\u015fullar alt\u0131nda kullan\u0131lmas\u0131 nedeniyle s\u0131n\u0131rl\u0131 g\u00f6r\u00fcnmektedir. Exposure’un m\u00fcmk\u00fcn oldu\u011fu ba\u015fl\u0131ca faaliyet, manuel bak\u0131m veya temizlik \u00e7al\u0131\u015fmalar\u0131 s\u0131ras\u0131nda ger\u00e7ekle\u015fmektedir. <\/p>\n

Madde hakk\u0131nda daha fazla bilgi<\/h2>\n

Saf haliyle 1,2-DPC, kloroform benzeri bir kokuya sahip, renksiz, yan\u0131c\u0131 ve ak\u0131\u015fkan bir s\u0131v\u0131d\u0131r. Alkoller, esterler ve ketonlar gibi \u00e7o\u011fu organik \u00e7\u00f6z\u00fcc\u00fcyle ve ayr\u0131ca aromatik, alifatik ve klorlu hidrokarbonlarla kar\u0131\u015fabilir.
\nAB genelinde ge\u00e7erli olacak ba\u011flay\u0131c\u0131 bir mesleki exposure s\u0131n\u0131r de\u011feri \u015fu anda haz\u0131rlanmaktad\u0131r. <\/p>\n

Olu\u015fabilecek tehlikeler<\/h2>\n

\u0130nsanlarda 1,2-DCP\u2019ye k\u0131sa s\u00fcreli exposure, a\u011f\u0131z yoluyla ve deri yoluyla emilimin ard\u0131ndan tahri\u015fin yan\u0131 s\u0131ra karaci\u011fer ve b\u00f6brek fonksiyon bozukluklar\u0131na neden olabilir. \u00c7ok y\u00fcksek konsantrasyonlarda, merkezi sinir sistemi depresyonu vakalar\u0131 bildirilmi\u015ftir.
\nUzun s\u00fcreli exposure, insanlarda en kritik etki carcinogenlik, \u00f6zellikle de safra kanal\u0131 t\u00fcm\u00f6rlerinin (kolanjiyokarsinom) ortaya \u00e7\u0131kmas\u0131d\u0131r. <\/p>\n

Yapabilecekleriniz<\/h2>\n

\u0130\u015fyerinde exposure\u2019\u0131 \u00f6nlemenin en etkili yolu, 1,2-DCP\u2019nin ikame edilmesidir. \u0130kame m\u00fcmk\u00fcn olmad\u0131\u011f\u0131nda ve 1,2-DCP kullan\u0131m\u0131ndan ka\u00e7\u0131n\u0131lamad\u0131\u011f\u0131nda, exposure\u2019\u0131 azaltmaya y\u00f6nelik \u00f6nlemler al\u0131nmal\u0131d\u0131r.
\n1,2-DCP’ye maruz kalmay\u0131 \u00f6nlemenin en etkili yolu, kapal\u0131 sistemler geli\u015ftirmek ve kullanmakt\u0131r. Bunun m\u00fcmk\u00fcn olmad\u0131\u011f\u0131 durumlarda, exposure’un teknik olarak m\u00fcmk\u00fcn oldu\u011funca en aza indirilmesini sa\u011flamak i\u00e7in, etkili yerel egzoz havaland\u0131rmas\u0131 gibi teknik \u00f6nlemler al\u0131nmal\u0131 ve bu \u00f6nlemler, iyi bir genel i\u015fyeri havaland\u0131rmas\u0131 ve bunlar\u0131n etkinli\u011finin d\u00fczenli olarak kontrol edilmesi ile desteklenmelidir. <\/p>\n

1,2-DPC\u2019nin t\u00fcm \u00fcretimi kapal\u0131 sistemler i\u00e7inde ger\u00e7ekle\u015ftirilir. Exposure, bu kapal\u0131 sistemlerin rutin bak\u0131m, denetim veya temizlik amac\u0131yla a\u00e7\u0131lmas\u0131 durumunda meydana gelir. Bu durumlarda, solunum koruyucu ekipman (RPE) dahil olmak \u00fczere teknik \u00f6nlemlerin ve ki\u015fisel koruyucu donan\u0131m\u0131n (KKD) kullan\u0131lmas\u0131 gerekmektedir. <\/p>\n

D\u00fczenli temizlik ve hijyenik depolama yoluyla i\u015fyerinde genel hijyenin uygun \u015fekilde sa\u011flanmas\u0131na y\u00f6nelik \u00f6nlemler al\u0131n. Risk de\u011ferlendirmesi i\u00e7in yap\u0131lan ilk exposure \u00f6l\u00e7\u00fcm\u00fcn\u00fcn ard\u0131ndan, mevcut teknik \u00f6nlemlerin etkili olup olmad\u0131\u011f\u0131n\u0131 veya ilave \u00f6nlemlerin al\u0131nmas\u0131 gerekip gerekmedi\u011fini kontrol etmek amac\u0131yla periyodik exposure de\u011ferlendirmeleri ger\u00e7ekle\u015ftirin. \u00c7al\u0131\u015fanlar\u0131n maruz kal\u0131nan \u00e7al\u0131\u015fma ortam\u0131nda ge\u00e7irdikleri s\u00fcreyi (\u00f6rne\u011fin vardiyalar yoluyla) s\u0131k\u0131 bir \u015fekilde s\u0131n\u0131rlamak ve bu i\u015fyerlerine eri\u015fimi k\u0131s\u0131tlamak, exposure’u azaltmak i\u00e7in \u00f6nemli \u00f6nlemlerdir. \u00c7al\u0131\u015fanlar, 1,2-DPC ile ilgili g\u00f6revlerin getirebilece\u011fi olas\u0131 risklerin fark\u0131nda olmal\u0131 ve i\u015fverenler, 1,2-DPC ile g\u00fcvenli \u00e7al\u0131\u015fma konusunda \u00e7al\u0131\u015fanlara d\u00fczenli olarak e\u011fitim ve talimat vermelidir. <\/p>\n

Tehlikeli maddelere maruz kalan \u00e7al\u0131\u015fanlar i\u00e7in t\u0131bbi sa\u011fl\u0131k g\u00f6zetimi zorunludur ve bu nedenle, solunum sorunlar\u0131 veya cilt alerjileri gibi erken belirtileri bildirmeleri konusunda te\u015fvik edilmelidirler.
\nAyr\u0131ca, \u00e7al\u0131\u015fanlara etkili ki\u015fisel hijyenin \u00f6nemi konusunda e\u011fitim verilmelidir. Yeterli y\u0131kama ve tuvalet imk\u00e2nlar\u0131 sa\u011flanmal\u0131 ve \u00e7al\u0131\u015fanlara hijyen \u00f6nlemlerini almalar\u0131 i\u00e7in yeterli zaman tan\u0131nmal\u0131d\u0131r. <\/p>\n

Gerekirse, \u00e7al\u0131\u015fanlar\u0131n koruyucu giysi ve eldiven gibi uygun ki\u015fisel koruma donan\u0131m\u0131na sahip olmalar\u0131n\u0131 sa\u011flay\u0131n. Ki\u015fisel koruma donan\u0131m\u0131, ancak son \u00e7are olarak ve olas\u0131 teknik ve organizasyonel \u00e7\u00f6z\u00fcmlerin t\u00fcm\u00fc t\u00fckendikten sonra ge\u00e7ici bir \u00f6nlem olarak kullan\u0131lmal\u0131d\u0131r. <\/p>\n

Kaynaklar: ECHA, ATSDR 2021<\/em><\/p>\n","protected":false},"template":"","carcinogens":[8667],"class_list":["post-106564","fact","type-fact","status-publish","hentry","carcinogens-12-dikloropropan"],"yoast_head":"\n1,2-Dikloropropan - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"Be aware of what you work with! We collected all the important information these causing substances in easy-to-understand factsheets.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/stopcarcinogensatwork.eu\/tr\/fact\/12-dikloropropan\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"1,2-Dikloropropan\" \/>\n<meta property=\"og:description\" content=\"Be aware of what you work with! 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