{"id":57904,"date":"2023-08-29T10:09:24","date_gmt":"2023-08-29T10:09:24","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/14-dioxane\/"},"modified":"2026-06-13T11:31:52","modified_gmt":"2026-06-13T11:31:52","slug":"14-dioxane","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/tr\/fact\/14-dioxane\/","title":{"rendered":"1,4-Dioksan"},"content":{"rendered":"

AB\u2019de 30.000\u2019e yak\u0131n \u00e7al\u0131\u015fan\u0131n 1,4-Dioksana maruz kald\u0131\u011f\u0131 tahmin edilmektedir. 1,4-Dioksan\u0131n kullan\u0131ld\u0131\u011f\u0131 tipik i\u015fyerleri, kau\u00e7uk ve kimya end\u00fcstrisindedir. Ayr\u0131ca kozmetik end\u00fcstrisinde bir yan \u00fcr\u00fcn olarak da ortaya \u00e7\u0131kabilir. \u00c7al\u0131\u015fanlar esas olarak havadaki kirlenme ve deri temas\u0131 yoluyla maruz kalmaktad\u0131r, ancak a\u011f\u0131z yoluyla exposure da m\u00fcmk\u00fcnd\u00fcr. 1,4-Dioksan, S\u0131n\u0131fland\u0131rma, Etiketleme ve Ambalajlama mevzuat\u0131na g\u00f6re kategori 1B carcinogen olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r (Carc. 1B) ve burun kanserinin yan\u0131 s\u0131ra karaci\u011fer ve b\u00f6brek t\u00fcm\u00f6rlerine de katk\u0131da bulundu\u011fu \u015f\u00fcphelenilmektedir. Ayr\u0131ca, 1,4-Dioksan ciddi g\u00f6z tahri\u015fine neden olur ve solunum yollar\u0131nda tahri\u015fe yol a\u00e7abilir; cilde tekrar tekrar exposure g\u00f6stermek ciltte kurulu\u011fa veya \u00e7atlamaya neden olabilir. <\/p><\/blockquote>\n

Risklerin ortaya \u00e7\u0131kt\u0131\u011f\u0131 yerler<\/h2>\n

Mesleki exposure occurs during the production, processing, and use of 1,4-Dioksan, via inhalation or dermal exposure. 1,4-Dioksan is often used as a solvent in laboratories (for example, as a mobile phase in chromatography) and at industrial sites during polymerization processes. Temizlik ve bak\u0131m faaliyetleri de exposure a\u00e7\u0131s\u0131ndan dikkate al\u0131nmas\u0131 gereken \u00f6nemli unsurlard\u0131r. <\/p>\n

Madde hakk\u0131nda daha fazla bilgi<\/h2>\n

1,4-Dioksan, di\u011fer \u00e7\u00f6z\u00fcc\u00fclerle kolayca kar\u0131\u015fan berrak, renksiz bir s\u0131v\u0131d\u0131r. \u0130nert yap\u0131s\u0131 nedeniyle esas olarak \u00e7\u00f6z\u00fcc\u00fc olarak kullan\u0131l\u0131r. Son derece yan\u0131c\u0131d\u0131r ve patlay\u0131c\u0131 peroksitler olu\u015fturabilir. 1,4-Dioksan, do\u011fada do\u011fal olarak bulunmayan, insan kaynakl\u0131 bir kimyasald\u0131r. End\u00fcstriyel etoksilasyon i\u015flemlerinin bilinen bir yan \u00fcr\u00fcn\u00fcd\u00fcr ve bu nedenle kozmetik ve ki\u015fisel bak\u0131m \u00fcr\u00fcnlerinde kirletici olarak bulunabilir; bu \u00fcr\u00fcnlerde konsantrasyonu s\u0131k\u0131 bir \u015fekilde d\u00fczenlenmi\u015ftir. 1,4-Dioksan ayr\u0131ca plastik ve kau\u00e7uk \u00fcr\u00fcnlerde (\u00f6r. eldivenler, botlar, giysiler, kau\u00e7uk saplar, vites kolu, direksiyon simidi) kal\u0131nt\u0131 olarak da bulunmu\u015ftur. <\/p>\n

1,4-Dioksan suda kararl\u0131d\u0131r ve par\u00e7alanmaz. Havadaki bile\u015fikler, 1,4-Dioksan\u0131 h\u0131zla farkl\u0131 bile\u015fiklere par\u00e7alayabilir. 1,4-Dioksan i\u00e7eren kimyasal \u00e7\u00f6z\u00fcc\u00fclerin bertaraf\u0131 ve 1,4-Dioksan kendisinin bertaraf\u0131 ile ilgili olarak \u00e7evrede (yeralt\u0131 sular\u0131nda) kirlilik mevcuttur. <\/p>\n

Olu\u015fabilecek tehlikeler<\/h2>\n

1,4-Dioksan, solunum yoluyla ve a\u011f\u0131zdan maruz kal\u0131nd\u0131\u011f\u0131nda h\u0131zla ve neredeyse tamamen emilir. Deri yoluyla emilim de \u00f6nemlidir. 1,4-Dioksan solunduktan sonra \u00fcst kar\u0131n a\u011fr\u0131s\u0131 ve kusma ile birlikte g\u00f6zlerde ve solunum yollar\u0131nda tahri\u015f g\u00f6r\u00fclebilir. 1,4-Dioksan zehirlenmesinin di\u011fer belirtileri aras\u0131nda karaci\u011fer ve b\u00f6brek hasar\u0131, kas\u0131lmalar ve koma yer al\u0131r. Bu ba\u011flamda, maddenin e\u015fzamanl\u0131 dermal emilimi de dikkate al\u0131nmal\u0131d\u0131r. Ayr\u0131ca, 1,4-Dioksana tekrarlanan dermal exposure cilt hasar\u0131na yol a\u00e7abilir. Ek olarak, hayvan \u00e7al\u0131\u015fmalar\u0131nda karaci\u011fer ve b\u00f6brekler \u00fczerinde etkilerin yan\u0131 s\u0131ra, sendelemeli y\u00fcr\u00fcy\u00fc\u015f, narkoz, fel\u00e7 ve koma gibi merkezi sinir sistemi \u00fczerinde etkiler de g\u00f6zlemlenmi\u015ftir. Uzun s\u00fcreli exposure’un ard\u0131ndan ana hedef organlar\u0131n solunum sistemi, karaci\u011fer ve b\u00f6brekler oldu\u011fu unutulmamal\u0131d\u0131r. <\/p>\n

Yapabilecekleriniz<\/h2>\n

M\u00fcmk\u00fcn oldu\u011fu durumlarda, maddenin ikamesi d\u00fc\u015f\u00fcn\u00fclmelidir. Alternatifler mevcut de\u011filse veya 1,4-Dioksan bir yan \u00fcr\u00fcn olarak ortaya \u00e7\u0131kabiliyorsa, ne zaman ve nerede \u00f6nlem al\u0131nmas\u0131 gerekti\u011finin bilinmesi i\u00e7in d\u00fczenli aral\u0131klarla uygun exposure \u00f6l\u00e7\u00fcmleri yap\u0131lmal\u0131d\u0131r. Dolay\u0131s\u0131yla, olumsuz sa\u011fl\u0131k etkilerini \u00f6nlemek i\u00e7in exposure’\u0131 sa\u011fl\u0131k temelli s\u0131n\u0131r de\u011ferinin alt\u0131na d\u00fc\u015f\u00fcrmek son derece \u00f6nemlidir. End\u00fcstriyel s\u00fcre\u00e7lerde teknik kontrol \u00f6nlemlerine \u00f6rnek olarak kapal\u0131 sistemler, genel egzoz ve yerel egzoz havaland\u0131rmas\u0131 verilebilir. Kapal\u0131 sistemlerle \u00e7al\u0131\u015f\u0131rken bile, \u00f6rne\u011fin numune alma i\u015flemleri s\u0131ras\u0131nda exposure meydana gelebilir. Bu durumlarda \u00f6l\u00e7\u00fcmler ve kontrol \u00f6nlemleri \u00f6nemlidir. \u00d6nerilen di\u011fer \u00e7al\u0131\u015fma uygulamalar\u0131 aras\u0131nda \u00e7al\u0131\u015fanlara tehlike bilgileri ve e\u011fitimi verilmesi ile kimyasal madde kullan\u0131m alanlar\u0131 i\u00e7in genel \u00e7al\u0131\u015fma hijyeni standartlar\u0131 yer al\u0131r. Bak\u0131m ve temizlik \u00e7al\u0131\u015fanlar\u0131 da e\u011fitilmelidir. \u00c7al\u0131\u015fanlar\u0131n erken semptomlar bildirip bildirmedi\u011fini ara\u015ft\u0131r\u0131n. Bir i\u015f sa\u011fl\u0131\u011f\u0131 uzman\u0131n\u0131n dahil edilmesi \u00f6nerilir. 1,4-Dioksan i\u00e7in exposure de\u011ferlendirmesinin, ulusal mevzuata uygunsa biyomonitoring ile desteklenebilece\u011fini unutmay\u0131n. \u00c7al\u0131\u015fanlar exposure’un etkilerinin fark\u0131nda olmal\u0131d\u0131r. Ki\u015fisel koruma donan\u0131m\u0131, ancak olas\u0131 m\u00fchendislik \u00e7\u00f6z\u00fcmleri uyguland\u0131ktan sonra, son \u00e7are olarak kullan\u0131lmal\u0131d\u0131r. <\/p>\n

Kaynaklar: BAuA, S\u0131n\u0131fland\u0131rma, Etiketleme ve Ambalajlama, Alman MAK Komisyonu, RAC<\/em><\/p>\n","protected":false},"template":"","carcinogens":[2573],"class_list":["post-57904","fact","type-fact","status-publish","hentry","carcinogens-14-dioxane-tr"],"yoast_head":"\n1,4-Dioksan - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"AB'de 30.000 \u00e7al\u0131\u015fan 1,4-Dioksana maruz kalmaktad\u0131r. 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