{"id":57905,"date":"2023-08-29T10:09:26","date_gmt":"2023-08-29T10:09:26","guid":{"rendered":"https:\/\/stopcarcinogensatwork.eu\/fact\/izopren\/"},"modified":"2026-06-13T11:31:46","modified_gmt":"2026-06-13T11:31:46","slug":"izopren","status":"publish","type":"fact","link":"https:\/\/stopcarcinogensatwork.eu\/tr\/fact\/izopren\/","title":{"rendered":"\u0130zopren"},"content":{"rendered":"

AB\u2019de 10.539 \u00e7al\u0131\u015fan\u0131n izopren maruziyetine maruz kalabilece\u011fi tahmin edilmektedir. \u0130zoprenin \u00fcretildi\u011fi veya kullan\u0131ld\u0131\u011f\u0131 i\u015fyerlerinde exposure, \u00f6ncelikle buharlar\u0131n solunmas\u0131 ve cilt temas\u0131 yoluyla ger\u00e7ekle\u015febilir; ancak dermal emilim ihmal edilebilir d\u00fczeyde kabul edilmektedir. S\u0131n\u0131fland\u0131rma, Etiketleme ve Ambalajlama’ya g\u00f6re, izopren carcinogen kategori 1B (H350: Kansere neden olabilir) olarak s\u0131n\u0131fland\u0131r\u0131lm\u0131\u015ft\u0131r. Kronik ve y\u00fcksek d\u00fczeyde exposure, ana etki olarak karaci\u011fer kanserine yol a\u00e7abilece\u011fi gibi, anemiye, koku epitelinin (burun bo\u015flu\u011funun i\u00e7inde koku alg\u0131lamada rol oynayan doku) dejenerasyonuna ve omurilik beyaz maddesinin dejenerasyonuna da yol a\u00e7abilir. <\/p><\/blockquote>\n

Risklerin olu\u015ftu\u011fu yerler<\/h2>\n

\u0130zopren, polimer \u00fcretimi ve i\u015flenmesinde bir monomer olarak kullan\u0131l\u0131r. Ayr\u0131ca, kimyasal maddelerin sentezinde bir ara madde olarak da kullan\u0131l\u0131r. \u0130zoprene maruz kalma, bu maddenin \u00fcretimi s\u0131ras\u0131nda veya s\u00fcrd\u00fcr\u00fclebilir havac\u0131l\u0131k yak\u0131t\u0131 olarak kullan\u0131ld\u0131\u011f\u0131nda da meydana gelebilir. End\u00fcstriyel kimyasallar\u0131n ve kimyasal \u00fcr\u00fcnlerin imalat\u0131 ile plastik ve kau\u00e7uk \u00fcr\u00fcnlerin \u00fcretimi sekt\u00f6rlerinde \u00e7al\u0131\u015fanlar, bu maddeye maruz kalma riski alt\u0131ndad\u0131r. <\/p>\n

Madde hakk\u0131nda daha fazla bilgi<\/h2>\n

\u0130zopren, hafif kokulu, renksiz ve yan\u0131c\u0131 bir s\u0131v\u0131d\u0131r. Kaynama noktas\u0131 sadece 34 \u00b0C gibi d\u00fc\u015f\u00fckt\u00fcr ve bu nedenle 21,1 \u00b0C\u2019de bile 634 hPa gibi son derece y\u00fcksek bir buhar bas\u0131nc\u0131na sahiptir. Bu, oda s\u0131cakl\u0131\u011f\u0131nda h\u0131zla buharla\u015ft\u0131\u011f\u0131 anlam\u0131na gelir. Serbest kalan buharlar solunabilir veya patlay\u0131c\u0131 bir ortam olu\u015fturabilir. \u0130zopren, bir\u00e7ok bitki, hayvan ve insanda do\u011fal olarak bulunan bir metabolittir. \u0130zopren, bir\u00e7ok a\u011fa\u00e7 t\u00fcr\u00fc taraf\u0131ndan b\u00fcy\u00fck miktarlarda sal\u0131n\u0131r (ancak h\u0131zla bozunur, bu da \u00e7evresel konsantrasyonlar\u0131n d\u00fc\u015f\u00fck oldu\u011fu anlam\u0131na gelir) ve insan nefesinde de tespit edilebilir. \u0130zoprenin kendisi genotoksik de\u011fildir, ancak a\u011f\u0131rl\u0131kl\u0131 olarak karaci\u011ferde genotoksik bir mono- ve diepokside kolayca metabolize olur. \u0130zopren polimerleri, do\u011fal kau\u00e7u\u011fun ana bile\u015fenidir. \u0130zoprenden yap\u0131lan en yayg\u0131n \u00fcr\u00fcnler lastiklerdir. <\/p>\n

Olu\u015fabilecek tehlikeler<\/h2>\n

\u0130\u015fyerinde izopren maruziyetinin en y\u00fcksek riski, buharlar\u0131n solunmas\u0131 yoluyla ortaya \u00e7\u0131kar. \u0130zopren tek seferlik veya k\u0131sa s\u00fcreli maruziyet, burun, bo\u011faz ve akci\u011ferlerde tahri\u015fe neden olabilir ve ba\u015f a\u011fr\u0131s\u0131 veya ba\u015f d\u00f6nmesine yol a\u00e7abilir. Akut toksisite d\u00fc\u015f\u00fck olmakla birlikte (yani, tek bir k\u0131sa s\u00fcreli exposure sonucu \u00f6l\u00fcm olas\u0131l\u0131\u011f\u0131 \u00e7ok d\u00fc\u015f\u00fckt\u00fcr), izopren’e uzun s\u00fcreli veya tekrarlanan exposure, karaci\u011fer kanseri, koku epitelinin dejenerasyonu ve omurilik beyaz maddesinin dejenerasyonu ile ili\u015fkilidir. <\/p>\n

Karaci\u011fer kanseri i\u00e7in gizli d\u00f6nem s\u00fcresinin 18 y\u0131l oldu\u011fu tahmin edilmektedir.<\/strong><\/p>\n

Yapabilecekleriniz<\/h2>\n

Exposure can be prevented by replacing izopren with safer alternatives. If replacing izopren is not possible and its use is unavoidable, measures to reduce exposure must be taken. \u0130zoprenin kullan\u0131m\u0131ndan de\u011fil, \u00fcretiminden sorumlu olan ar\u0131t\u0131lm\u0131\u015f petrol \u00fcr\u00fcnlerinin imalat\u0131nda ikame uygulanamaz. Ancak, kau\u00e7uk end\u00fcstrisinde di\u011fer monomerlerin kullan\u0131lmas\u0131 bir se\u00e7enek olabilir. \u0130zopren maruz kalmay\u0131 \u00f6nlemenin ikinci en etkili yolu, kapal\u0131 sistemler geli\u015ftirmek ve kullanmakt\u0131r. Kapal\u0131 sistemler, izoprenin rafine edilmesi ve polimerizasyonu s\u00fcre\u00e7lerinin t\u00fcm\u00fcnde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. <\/p>\n

Maddenin ikamesi veya kapal\u0131 bir prosesin uygulanmas\u0131n\u0131n m\u00fcmk\u00fcn olmad\u0131\u011f\u0131 durumlarda, exposure’un teknik olarak m\u00fcmk\u00fcn oldu\u011funca en aza indirilmesini sa\u011flamak i\u00e7in etkili yerel egzoz havaland\u0131rmas\u0131 veya i\u015fyerinin iyi havaland\u0131r\u0131lmas\u0131 gibi teknik \u00f6nlemler al\u0131nmal\u0131 ve bu \u00f6nlemlerin etkinli\u011fi kontrol edilmelidir. \u0130zopren genellikle buharla\u015fmay\u0131 azaltmada olduk\u00e7a etkili olan bas\u0131n\u00e7l\u0131 kontrol kabinlerinde i\u015flenir. <\/p>\n

Mevcut koruyucu \u00f6nlemlerinizin etkili olup olmad\u0131\u011f\u0131n\u0131 veya ilave \u00f6nlemlerin al\u0131nmas\u0131 gerekip gerekmedi\u011fini kontrol etmek i\u00e7in d\u00fczenli exposure de\u011ferlendirmeleri yap\u0131n. \u00c7al\u0131\u015fanlar, exposure’un etkilerinin fark\u0131nda olmal\u0131 ve exposure’u \u00f6nlemek amac\u0131yla \u0130zopren ile g\u00fcvenli bir \u015fekilde \u00e7al\u0131\u015fmak i\u00e7in gerekli kontrol \u00f6nlemleri konusunda d\u00fczenli olarak e\u011fitilmelidir. Burun, bo\u011faz ve akci\u011ferlerde tahri\u015f (\u00f6r. \u00f6ks\u00fcr\u00fck ve h\u0131r\u0131lt\u0131l\u0131 solunum), ba\u015f a\u011fr\u0131s\u0131 veya ba\u015f d\u00f6nmesi gibi semptomlar\u0131 bildirmeleri i\u00e7in te\u015fvik edilmelidir, \u00e7\u00fcnk\u00fc bunlar mevcut \u00f6nlemlerin yeterli olmad\u0131\u011f\u0131na dair uyar\u0131 i\u015faretleri olabilir. Bir i\u015f sa\u011fl\u0131\u011f\u0131 hekiminin s\u00fcrece dahil edilmesi \u00f6nerilir. <\/p>\n

Ayr\u0131ca, \u00e7al\u0131\u015fanlara etkili hijyen \u00f6nlemleri konusunda e\u011fitim verin.<\/p>\n

Gerekirse, \u00e7al\u0131\u015fanlar\u0131n koruyucu giysi ve eldiven gibi uygun ki\u015fisel koruma donan\u0131m\u0131 (KKD) sahip oldu\u011fundan emin olun. Yeniden kullan\u0131labilir KKD kullan\u0131l\u0131yorsa, bunlar\u0131n temizlenmesine veya gerekirse de\u011fi\u015ftirilmesine ve temiz bir yerde saklanmas\u0131na \u00f6zen g\u00f6sterin. \u0130zopren i\u00e7in genellikle RPE (solunum koruyucu ekipman) ile koruyucu eldiven ve g\u00f6zl\u00fck gereklidir. Solunum ekipman\u0131 gerekliyse, solunumun fiziksel olarak ek bir zorluk yaratmad\u0131\u011f\u0131ndan emin olun. Ki\u015fisel koruma ekipman\u0131, ancak son \u00e7are olarak ve olas\u0131 teknik \u00e7\u00f6z\u00fcmler t\u00fckenmi\u015fse ge\u00e7ici olarak kullan\u0131lmal\u0131d\u0131r. <\/p>\n

Kaynaklar: ECHA, RAC, DG EMPL<\/em><\/p>\n","protected":false},"template":"","carcinogens":[2574],"class_list":["post-57905","fact","type-fact","status-publish","hentry","carcinogens-izopren"],"yoast_head":"\n\u0130zopren - STOP carcinogens at work<\/title>\n<meta name=\"description\" content=\"AB\u2019de 10.539 \u00e7al\u0131\u015fan\u0131n \u0130zopren maruziyetine maruz kalabilece\u011fi tahmin edilmektedir. 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