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70% ethanol as an alternative to formalin in tissue fixation

70% ethanol as an alternative to formalin in tissue fixation

Type of measure: Substitution

The study

A study aimed to use a systematic approach to evaluate the biomolecular status of a number of clinical tissue specimens processed through a non-formalin fixation method. 50 radical prostatectomies (tissue from prostate) were fixed in 70% ethanol and studied at the National Cancer Institute.

Results

The conclusion was that specimens fixed in 70% ethanol and embedded in paraffin produce good histology and permit recovery of DNA, mRNA, and proteins sufficient for several downstream molecular analyses.

More information
Read the full description of this solution on SUBSPORTplus
Published July 26, 2023
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