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The facts on Vinyl Chloride

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The facts on Vinyl Chloride

Last update September 3, 2024

Estimates of current numbers of exposed workers to Vinyl Chloride in the EU are not available. In 1993, a number of 40,000 exposed workers for the EU 15 was estimated.

Exposure to vinyl chloride mainly occurs through inhalation. Prolonged exposure can cause cancer in the liver, brain, blood and lungs. Vinyl chloride has a harmonised classification under the CLP regulation as Carcinogenic Category 1A, which means it may cause cancer in humans.

Where risks occur

The main route of occupational exposure to vinyl chloride is by inhalation, which occurs mainly in (poly) vinyl chloride (PVC) plants and in PVC-processing plants (including packaging, storage and handling of vinyl chloride). Workers in the sectors of manufacture of industrial chemicals, plastic products, fabricated metal products or machinery are at risk as well as workers occupied in services allied to transport and construction.

More about the substance

Vinyl chloride is a colorless gas that burns easily. It has a mild, sweet odor, but the odor is not an adequate warning of hazardous concentrations. It does not occur naturally and must be produced industrially for its commercial uses. Vinyl chloride is used primarily to make PVC; PVC is used to make a variety of plastic products, including pipes, wire and cable coatings and packaging materials. Vinyl chloride is also present in tobacco smoke.

How symptoms can affect you

Acute exposure to vinyl chloride can lead to symptoms such as weakness, dizziness, fatigue, weight loss, numbness and tingling of the extremities, visual disturbances and in severe cases coma and death. It can also irritate the eyes, skin, mucous membranes and respiratory tract. At low exposure levels, the body is able to process vinyl chloride and excrete it in urine. Chronic exposure can cause permanent liver damage and liver cancer, neurologic or behavioral symptoms and changes to the skin and bones of the hand.

The latency period between exposure and vinyl chloride related cancers varies strongly depending on the different types of cancer.

What you can do

The most effective way to prevent exposure is to substitute with vinyl chloride-free or lower-vinyl chloride oxide products. If vinyl chloride-containing products cannot be substituted, the exposure to vinyl chloride should be reduced through engineering controls, e. g. closed systems. In case this is not possible, install non-sparking ventilation systems and provide eyewash and safety shower if contact or splash hazard exists. Periodically carry out representative exposure measurements so that it is known when and where action should be taken. Make workers continuously aware of the effects of exposure and encourage them to report early symptoms.. In addition, train workers on hazards, safe work practices and on effective hygiene measures. Personal protective equipment (PPE) should only be used as a last resort, after introducing the possible engineering solutions. PPE includes safety goggles, chemical resistant clothing and gloves (chemical resistant or insulated) and respirators.

References: cancer.gov, OSHA, IARC, CDC

Limit values

EU
2,6 mg/m³
 Austria
2,6 mg/m³ (TWA)
20 mg/m³ short term
 Belgium
2,6 mg/m3
Bulgaria
EU directive
Croatia
EU directive
Czech Republic
EU directive
Cyprus
EU directive
Denmark
2,6 mg/m³ (TWA)
6 mg/m³ short term
Estonia
EU directive
Finland
2,6 mg/m³ (TWA)
France
2,59 mg/m³ (TWA)
Germany
2,6 mg/m³ (TWA)
20,8 mg/m³ short term
Greece
EU directive
Hungary
2,6 mg/m³ (TWA)
Iceland
EU directive
Ireland
2,6 mg/m³ (TWA)
Italy
2,6 mg/m³ (TWA)
Latvia
2,6 mg/m³ (TWA)
Lithuania
EU directive
Luxembourg
EU directive
Malta
EU directive
Netherlands
8h-TWA = 2.6 mg/m3 (1 ppm)
North Macedonia
7,77 mg/m³ (TWA)
Norway
2,6 mg/m³ (TWA)
Poland
EU directive
Portugal
EU directive
Romania
2,6 mg/m³ (TWA)
Serbia
EU directive
Slovakia
EU directive
Slovania
EU directive
Spain
VLA-ED= 1 ppm (2,6 mg/m3)
Sweden
2,5 mg/m³ (TWA)
13 mg/m³ short term
Turkey
7,77 mg/m³ (TWA)

References: cancer.gov, EFSA, IARC, EC, NIOSH, OSHA, CAREX

Possible substitutions

ECHA registration
CAS number 75-01-4
EC number 200-831-0
Annex VI of CLP 1A
Number of registrations (2023) 107
Tonnage band registred (2023) ≥ 1 000 000 tonnes per annum

The European Chemicals Agency (ECHA) works for the safe use of chemicals. It implements the EU’s groundbreaking chemicals legislation, benefiting human health, the environment and innovation and competitiveness in Europe.

GESTIS Database

The data pool may be used for the purpose of occupational health and safety or to obtain information on the hazards posed by chemical substances.

General facts

Facts about cancer-causing agents:

  • The direct costs of carcinogen exposure at work across Europe are estimated at 2.4 billion Euros per year.
  • Every year, about 120.000 persons get cancer from exposure to carcinogens at work
  • Every year, almost 100.000 people die from cancer that was caused by exposure at work
  • Annually more than 100.000 people die because of work-related cancer.
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